EBI Personnel Directory Arkin, Adam
A thorough, systems-level understanding of bacterial metabolism, gene regulation, and stress response will help elucidate principles to help rationally engineer bacteria, including Z. mobilis, for improved biofuel production from lignocellulosic sources. This program uses automated sample preparation and automated, high-throughput microbial experiments for these studies, applying them to key organisms, starting with Zymomonas mobilis.
Several oleaginous yeast (Rhodosporidium toruloides, Lipomyces spp., Yarrowia lipo/ytica) are being studied to compare their genetic tractability and lipid productivities. The goal of the project is to identify the best strain for carrying out detailed functional genomic, QTL mapping, and metabolic engineering studies to make fatty acid-derived diesel-like fuels in oleaginous yeast. The team seeks to understand why oleaginous yeast exhibit high flux from glucose to fatty acids. This knowledge will also be used to improve advanced biofuel yields in other yeast hosts, such as Saccharomyces cerevisiae (started in 2012).